SCFD1 [The Human Chemical-Genetic Interaction Map Project]

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======= SCFD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCFD1
  * **<color #00a2e8>Official Name</color>**: sec1 family domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23256|23256]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVM8|Q8WVM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCFD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCFD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of autophagosome assembly|
|regulation of ER to Golgi vesicle-mediated transport|
|Golgi-associated vesicle|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|negative regulation of organelle assembly|
|toxin transport|
|vesicle docking involved in exocytosis|
|regulation of vacuole organization|
|syntaxin binding|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle docking|
|COPII vesicle coating|
|cis-Golgi network|
|vesicle coating|
|exocytic process|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|negative regulation of autophagy|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|vesicle targeting|
|Golgi cisterna membrane|
|vesicle budding from membrane|
|post-Golgi vesicle-mediated transport|
|protein N-terminus binding|
|organelle localization by membrane tethering|
|regulation of macroautophagy|
|establishment of vesicle localization|
|membrane docking|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of organelle assembly|
|negative regulation of cellular catabolic process|
|protein-containing complex binding|
|vesicle organization|
|negative regulation of catabolic process|
|regulation of autophagy|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|establishment of organelle localization|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|response to oxygen levels|
|response to toxic substance|
|regulation of vesicle-mediated transport|
|organelle localization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|exocytosis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|secretion|
|response to abiotic stimulus|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-3.33|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.89|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.2|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.98|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.94|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.94|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.93|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.8|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 597/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|24/28|
|bone|22/26|
|breast|25/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|20/21|
|liver|14/20|
|lung|63/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCFD1 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>