SCLT1 [The Human Chemical-Genetic Interaction Map Project]

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======= SCLT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCLT1
  * **<color #00a2e8>Official Name</color>**: sodium channel and clathrin linker 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132320|132320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96NL6|Q96NL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCLT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCLT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611399|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|clustering of voltage-gated sodium channels|
|clathrin complex|
|ciliary transition fiber|
|neuronal ion channel clustering|
|sodium channel regulator activity|
|neuron maturation|
|clathrin binding|
|ciliary basal body-plasma membrane docking|
|anatomical structure maturation|
|centriole|
|cell maturation|
|organelle localization by membrane tethering|
|membrane docking|
|protein C-terminus binding|
|developmental maturation|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|organelle localization|
|organelle assembly|
|neuron development|
|membrane organization|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.77|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.45|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.72|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.37|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|5.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.64|
|[[:human genes:o:odf2|ODF2]]|0.631|
|[[:human genes:c:c2cd3|C2CD3]]|0.614|
|[[:human genes:p:pibf1|PIBF1]]|0.598|
|[[:human genes:c:cep76|CEP76]]|0.596|
|[[:human genes:c:casp2|CASP2]]|0.595|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.566|
|[[:human genes:o:ofd1|OFD1]]|0.56|
|[[:human genes:c:ccdc41|CCDC41]]|0.558|
|[[:human genes:n:nin|NIN]]|0.548|
|[[:human genes:p:pidd|PIDD]]|0.547|
|[[:human genes:c:cep120|CEP120]]|0.547|
|[[:human genes:c:cep128|CEP128]]|0.542|
|[[:human genes:c:c14orf80|C14orf80]]|0.533|
|[[:human genes:c:c16orf59|C16orf59]]|0.525|
|[[:human genes:f:fopnl|FOPNL]]|0.479|
|[[:human genes:a:ankrd26|ANKRD26]]|0.473|
|[[:human genes:t:tube1|TUBE1]]|0.458|
|[[:human genes:c:cep78|CEP78]]|0.449|
|[[:human genes:r:rttn|RTTN]]|0.445|
|[[:human genes:t:tubd1|TUBD1]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCLT1 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>