SCLT1

Entrez Summary: This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

clustering of voltage-gated sodium channels
clathrin complex
ciliary transition fiber
neuronal ion channel clustering
sodium channel regulator activity
neuron maturation
clathrin binding
ciliary basal body-plasma membrane docking
anatomical structure maturation
centriole
cell maturation
organelle localization by membrane tethering
membrane docking
protein C-terminus binding
developmental maturation
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
organelle localization
organelle assembly
neuron development
membrane organization
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
generation of neurons
neurogenesis
cell development