SCN10A

Entrez Summary: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:9839820}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK2606414 1μM R05 exp236	-1.95
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.81
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.73
LJH685 50μM R08 exp433	1.83

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bundle of His cell action potential
bundle of His cell to Purkinje myocyte signaling
AV node cell action potential
AV node cell to bundle of His cell signaling
regulation of atrial cardiac muscle cell membrane depolarization
clathrin complex
AV node cell to bundle of His cell communication
bundle of His cell to Purkinje myocyte communication
voltage-gated sodium channel complex
voltage-gated sodium channel activity
cell-cell signaling involved in cardiac conduction
neuronal action potential
membrane depolarization during action potential
regulation of membrane depolarization
voltage-gated ion channel activity
cell communication involved in cardiac conduction
cardiac muscle cell action potential
membrane depolarization
transmission of nerve impulse
integral component of presynaptic membrane
sensory perception of pain
regulation of cardiac muscle contraction
odontogenesis of dentin-containing tooth
sodium ion transmembrane transport
regulation of striated muscle contraction
cardiac conduction
action potential
regulation of heart rate
odontogenesis
ion channel binding
multicellular organismal signaling
sodium ion transport
regulation of muscle contraction
regulation of muscle system process
regulation of heart contraction
regulation of blood circulation
axon
glutamatergic synapse
monovalent inorganic cation transport
regulation of membrane potential