SCN1B [The Human Chemical-Genetic Interaction Map Project]

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======= SCN1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCN1B
  * **<color #00a2e8>Official Name</color>**: sodium voltage-gated channel beta subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6324|6324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07699|Q07699]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCN1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCN1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600235|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. {ECO:0000269|PubMed:14622265}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticospinal neuron axon guidance|
|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|
|membrane depolarization during Purkinje myocyte cell action potential|
|Purkinje myocyte action potential|
|response to pyrethroid|
|regulation of voltage-gated sodium channel activity|
|Purkinje myocyte to ventricular cardiac muscle cell signaling|
|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|
|Purkinje myocyte to ventricular cardiac muscle cell communication|
|corticospinal tract morphogenesis|
|sodium channel inhibitor activity|
|regulation of atrial cardiac muscle cell membrane depolarization|
|action potential propagation|
|neuronal action potential propagation|
|voltage-gated sodium channel complex|
|node of Ranvier|
|response to insecticide|
|membrane depolarization during cardiac muscle cell action potential|
|voltage-gated sodium channel activity|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|central nervous system projection neuron axonogenesis|
|cell-cell signaling involved in cardiac conduction|
|regulation of cardiac muscle cell membrane repolarization|
|membrane depolarization during action potential|
|regulation of membrane repolarization|
|positive regulation of sodium ion transport|
|sodium channel regulator activity|
|central nervous system neuron axonogenesis|
|regulation of heart rate by cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|T-tubule|
|regulation of membrane depolarization|
|cell communication involved in cardiac conduction|
|voltage-gated ion channel activity|
|intercalated disc|
|cardiac muscle cell action potential|
|membrane depolarization|
|regulation of sodium ion transmembrane transporter activity|
|transmission of nerve impulse|
|regulation of sodium ion transmembrane transport|
|cardiac muscle contraction|
|central nervous system neuron development|
|heart contraction|
|regulation of sodium ion transport|
|actin-mediated cell contraction|
|sodium ion transmembrane transport|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|ion channel binding|
|perikaryon|
|multicellular organismal signaling|
|sodium ion transport|
|regulation of cation channel activity|
|central nervous system neuron differentiation|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|axon guidance|
|neuron projection guidance|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|axon development|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|response to toxic substance|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|ion homeostasis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|neuron differentiation|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|transmembrane transport|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCN1B Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>