SCN1B

Gene Information

Official Symbol: SCN1B
Official Name: sodium voltage-gated channel beta subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 6324
UniProt: Q07699
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
UniProt Summary: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. {ECO:0000269|PubMed:14622265}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9084
Expression level (log2 read counts): 1.84

Expression Distribution

ig
V-set

corticospinal neuron axon guidance
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
membrane depolarization during Purkinje myocyte cell action potential
Purkinje myocyte action potential
response to pyrethroid
regulation of voltage-gated sodium channel activity
Purkinje myocyte to ventricular cardiac muscle cell signaling
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Purkinje myocyte to ventricular cardiac muscle cell communication
corticospinal tract morphogenesis
sodium channel inhibitor activity
regulation of atrial cardiac muscle cell membrane depolarization
action potential propagation
neuronal action potential propagation
voltage-gated sodium channel complex
node of Ranvier
response to insecticide
membrane depolarization during cardiac muscle cell action potential
voltage-gated sodium channel activity
regulation of ventricular cardiac muscle cell membrane repolarization
central nervous system projection neuron axonogenesis
cell-cell signaling involved in cardiac conduction
regulation of cardiac muscle cell membrane repolarization
membrane depolarization during action potential
regulation of membrane repolarization
positive regulation of sodium ion transport
sodium channel regulator activity
central nervous system neuron axonogenesis
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
T-tubule
regulation of membrane depolarization
cell communication involved in cardiac conduction
voltage-gated ion channel activity
intercalated disc
cardiac muscle cell action potential
membrane depolarization
regulation of sodium ion transmembrane transporter activity
transmission of nerve impulse