SCX
Gene Information
- Official Symbol: SCX
- Official Name: scleraxis bHLH transcription factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 642658
- UniProt: Q7RTU7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| tendon formation |
| deltoid tuberosity development |
| tendon cell differentiation |
| sclerotome development |
| tendon development |
| positive regulation of gastrulation |
| heart valve formation |
| Sertoli cell differentiation |
| positive regulation of collagen biosynthetic process |
| bHLH transcription factor binding |
| positive regulation of collagen metabolic process |
| replacement ossification |
| endochondral ossification |
| face morphogenesis |
| positive regulation of cartilage development |
| regulation of collagen biosynthetic process |
| head morphogenesis |
| regulation of gastrulation |
| positive regulation of embryonic development |
| regulation of collagen metabolic process |
| body morphogenesis |
| collagen fibril organization |
| face development |
| E-box binding |
| skeletal muscle cell differentiation |
| heart valve morphogenesis |
| heart valve development |
| mesoderm formation |
| mesoderm morphogenesis |
| regulation of cartilage development |
| endochondral bone morphogenesis |
| cellular response to mechanical stimulus |
| chondrocyte differentiation |
| somite development |
| BMP signaling pathway |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| response to BMP |
| cellular response to BMP stimulus |
| formation of primary germ layer |
| bone morphogenesis |
| skeletal muscle tissue development |
| mesoderm development |
| embryonic skeletal system development |
| regulation of embryonic development |
| skeletal muscle organ development |
| male gonad development |
| development of primary male sexual characteristics |
| cellular response to transforming growth factor beta stimulus |
| male sex differentiation |
| gastrulation |
| response to transforming growth factor beta |
| cartilage development |
| appendage development |
| limb development |
| tissue homeostasis |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| transcription factor complex |
| gonad development |
| response to mechanical stimulus |
| development of primary sexual characteristics |
| mesenchyme development |
| connective tissue development |
| skeletal system morphogenesis |
| ossification |
| sex differentiation |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| multicellular organismal homeostasis |
| cellular response to external stimulus |
| extracellular matrix organization |
| anatomical structure homeostasis |
| extracellular structure organization |
| sequence-specific DNA binding |
| reproductive structure development |
| reproductive system development |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| supramolecular fiber organization |
| muscle structure development |
| protein heterodimerization activity |
| skeletal system development |
| cellular response to growth factor stimulus |
| heart development |
| response to growth factor |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| developmental process involved in reproduction |
| epithelial cell differentiation |
| enzyme linked receptor protein signaling pathway |
| head development |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| embryo development |
| negative regulation of cell death |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17753
- Expression level (log2 read counts): -1.17
Expression Distribution
SCX Expression in NALM6 Cells: -1.17
