SCYL2

Entrez Summary: N/A
UniProt Summary: Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L- lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system. {ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

receptor internalization involved in canonical Wnt signaling pathway
positive regulation of clathrin-dependent endocytosis
regulation of clathrin-dependent endocytosis
positive regulation of receptor internalization
positive regulation of receptor-mediated endocytosis
endosome to lysosome transport
regulation of receptor internalization
clathrin-coated vesicle
receptor internalization
canonical Wnt signaling pathway
positive regulation of endocytosis
regulation of receptor-mediated endocytosis
receptor metabolic process
lysosomal transport
vacuolar transport
negative regulation of canonical Wnt signaling pathway
regulation of endocytosis
negative regulation of Wnt signaling pathway
endosome membrane
receptor-mediated endocytosis
protein kinase activity
regulation of canonical Wnt signaling pathway
signaling receptor binding
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of vesicle-mediated transport
endocytosis
import into cell
perinuclear region of cytoplasm
protein phosphorylation
Golgi apparatus
positive regulation of transport
cell-cell signaling
positive regulation of cellular component organization
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling