SDC3

Entrez Summary: The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009].
UniProt Summary: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. {ECO:0000250, ECO:0000269|PubMed:11527150}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microspike
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Golgi lumen
glycosaminoglycan biosynthetic process
retinoid metabolic process
aminoglycan biosynthetic process
diterpenoid metabolic process
terpenoid metabolic process
isoprenoid metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
collagen-containing extracellular matrix
leukocyte migration
cell surface
carbohydrate derivative biosynthetic process
cellular lipid metabolic process
cell migration
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
identical protein binding
localization of cell
cell motility
lipid metabolic process
locomotion
organonitrogen compound biosynthetic process
movement of cell or subcellular component
macromolecule biosynthetic process
organic substance catabolic process
membrane