SDR16C5

Entrez Summary: N/A
UniProt Summary: Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269|PubMed:18926804}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

keratinocyte proliferation
retinal metabolic process
negative regulation of histone acetylation
positive regulation of histone deacetylation
negative regulation of peptidyl-lysine acetylation
negative regulation of protein acetylation
retinol dehydrogenase activity
positive regulation of protein deacetylation
regulation of histone deacetylation
activating transcription factor binding
retinol metabolic process
negative regulation of histone modification
regulation of protein deacetylation
cellular aldehyde metabolic process
transcriptional repressor complex
regulation of histone acetylation
negative regulation of chromatin organization
regulation of peptidyl-lysine acetylation
regulation of protein acetylation
primary alcohol metabolic process
lipid droplet
epithelial cell proliferation
positive regulation of histone modification
positive regulation of chromatin organization
retinoid metabolic process
diterpenoid metabolic process
chromatin
terpenoid metabolic process
cellular hormone metabolic process
negative regulation of chromosome organization
isoprenoid metabolic process
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
hormone metabolic process
transcription corepressor activity
alcohol metabolic process
transcription factor binding
regulation of chromosome organization
negative regulation of organelle organization