SEC13 [The Human Chemical-Genetic Interaction Map Project]

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======= SEC13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC13
  * **<color #00a2e8>Official Name</color>**: SEC13 homolog, nuclear pore and COPII coat complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6396|6396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55735|P55735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600152|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. {ECO:0000269|PubMed:8972206}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore outer ring|
|COPII-coated vesicle cargo loading|
|GATOR2 complex|
|COPII vesicle coat|
|positive regulation of TORC1 signaling|
|protein exit from endoplasmic reticulum|
|vesicle cargo loading|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|ER to Golgi transport vesicle membrane|
|intracellular transport of virus|
|host cell|
|transport of virus|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|multi-organism localization|
|multi-organism transport|
|Golgi vesicle budding|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|localization within membrane|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|vesicle targeting|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|vesicle budding from membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of TOR signaling|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|nuclear envelope|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|RNA transport|
|structural molecule activity|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|RNA localization|
|antigen processing and presentation|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|vesicle organization|
|lysosomal membrane|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of small molecule metabolic process|
|organelle localization|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of cellular response to stress|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|intracellular protein transport|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.37|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.13|
|[[:results:exp539|42°C R08 exp539]]|-2.03|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.71|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.72|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.77|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.77|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.84|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.86|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.89|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.9|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.02|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.04|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.04|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.05|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.06|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.1|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.13|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.14|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.18|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.44|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.56|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dtl|DTL]]|0.567|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.539|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.536|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.525|
|[[:human genes:p:psmb4|PSMB4]]|0.522|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.522|
|[[:human genes:s:ssh2|SSH2]]|0.513|
|[[:human genes:n:npipb5|NPIPB5]]|0.508|
|[[:human genes:z:znf106|ZNF106]]|0.501|
|[[:human genes:n:nup160|NUP160]]|0.498|
|[[:human genes:c:copg1|COPG1]]|0.495|
|[[:human genes:r:rbbp5|RBBP5]]|0.491|
|[[:human genes:n:nupl1|NUPL1]]|0.489|
|[[:human genes:a:ankle2|ANKLE2]]|0.489|
|[[:human genes:r:rps2|RPS2]]|0.488|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.482|
|[[:human genes:r:rad51|RAD51]]|0.482|
|[[:human genes:d:ddtl|DDTL]]|0.482|
|[[:human genes:c:chd4|CHD4]]|0.477|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.476|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.476|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.475|
|[[:human genes:c:c14orf93|C14orf93]]|0.475|
|[[:human genes:d:dock6|DOCK6]]|0.474|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.474|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.474|
|[[:human genes:c:cbwd5|CBWD5]]|0.471|
|[[:human genes:s:snrpa1|SNRPA1]]|0.468|
|[[:human genes:c:cbwd3|CBWD3]]|0.468|
|[[:human genes:s:slc6a17|SLC6A17]]|0.468|
|[[:human genes:c:ccna2|CCNA2]]|0.468|
|[[:human genes:p:polr2j3|POLR2J3]]|0.467|
|[[:human genes:o:orc6|ORC6]]|0.465|
|[[:human genes:m:med17|MED17]]|0.464|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.463|
|[[:human genes:h:hap1|HAP1]]|0.463|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.463|
|[[:human genes:o:orc1|ORC1]]|0.461|
|[[:human genes:c:cmya5|CMYA5]]|0.46|
|[[:human genes:v:vasn|VASN]]|0.46|
|[[:human genes:p:psmc1|PSMC1]]|0.459|
|[[:human genes:p:polr2d|POLR2D]]|0.459|
|[[:human genes:e:exosc5|EXOSC5]]|0.459|
|[[:human genes:r:rrn3|RRN3]]|0.457|
|[[:human genes:s:supt5h|SUPT5H]]|0.457|
|[[:human genes:n:nup153|NUP153]]|0.456|
|[[:human genes:c:chaf1a|CHAF1A]]|0.454|
|[[:human genes:c:cdc45|CDC45]]|0.454|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.454|
|[[:human genes:p:psmb2|PSMB2]]|0.454|
|[[:human genes:n:nup85|NUP85]]|0.453|
|[[:human genes:h:hivep3|HIVEP3]]|0.453|
|[[:human genes:p:prpf8|PRPF8]]|0.452|
|[[:human genes:c:cdc73|CDC73]]|0.452|
|[[:human genes:c:copb1|COPB1]]|0.452|
|[[:human genes:k:kctd17|KCTD17]]|0.451|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.45|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.45|
|[[:human genes:s:syt9|SYT9]]|0.449|
|[[:human genes:s:sel1l|SEL1L]]|0.448|
|[[:human genes:n:napa|NAPA]]|0.448|
|[[:human genes:d:disp2|DISP2]]|0.447|
|[[:human genes:t:trim52|TRIM52]]|0.447|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.446|
|[[:human genes:p:psmd3|PSMD3]]|0.446|
|[[:human genes:m:myt1l|MYT1L]]|0.445|
|[[:human genes:f:fam160a1|FAM160A1]]|0.445|
|[[:human genes:a:akirin2|AKIRIN2]]|0.445|
|[[:human genes:c:ctr9|CTR9]]|0.445|
|[[:human genes:c:cbwd6|CBWD6]]|0.444|
|[[:human genes:p:plekha4|PLEKHA4]]|0.443|
|[[:human genes:r:rps14|RPS14]]|0.443|
|[[:human genes:v:vps54|VPS54]]|0.44|
|[[:human genes:r:rps12|RPS12]]|0.44|
|[[:human genes:a:acsf2|ACSF2]]|0.439|
|[[:human genes:t:ticrr|TICRR]]|0.437|
|[[:human genes:a:arcn1|ARCN1]]|0.437|
|[[:human genes:t:tsg101|TSG101]]|0.437|
|[[:human genes:k:kif3c|KIF3C]]|0.436|
|[[:human genes:n:nufip2|NUFIP2]]|0.436|
|[[:human genes:a:aamp|AAMP]]|0.436|
|[[:human genes:t:tfip11|TFIP11]]|0.435|
|[[:human genes:m:mt1e|MT1E]]|0.435|
|[[:human genes:p:pola1|POLA1]]|0.435|
|[[:human genes:p:psmd6|PSMD6]]|0.434|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.433|
|[[:human genes:g:golga6a|GOLGA6A]]|0.432|
|[[:human genes:t:traip|TRAIP]]|0.432|
|[[:human genes:i:igfn1|IGFN1]]|0.431|
|[[:human genes:s:supt6h|SUPT6H]]|0.431|
|[[:human genes:s:sap30bp|SAP30BP]]|0.431|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.43|
|[[:human genes:c:cln6|CLN6]]|0.43|
|[[:human genes:z:znf830|ZNF830]]|0.43|
|[[:human genes:s:sf3a3|SF3A3]]|0.429|
|[[:human genes:p:psma6|PSMA6]]|0.429|
|[[:human genes:s:slc4a1|SLC4A1]]|0.429|
|[[:human genes:s:snip1|SNIP1]]|0.429|
|[[:human genes:p:psmd1|PSMD1]]|0.428|
|[[:human genes:c:csnk1a1|CSNK1A1]]|0.427|
|[[:human genes:e:eif4a3|EIF4A3]]|0.427|
|[[:human genes:p:psmc2|PSMC2]]|0.425|
|[[:human genes:n:nup62|NUP62]]|0.425|
|[[:human genes:z:zfand5|ZFAND5]]|0.424|
|[[:human genes:c:c3|C3]]|0.424|
|[[:human genes:c:cwc22|CWC22]]|0.423|
|[[:human genes:w:wdr87|WDR87]]|0.422|
|[[:human genes:s:sf3a1|SF3A1]]|0.422|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.421|
|[[:human genes:n:narfl|NARFL]]|0.421|
|[[:human genes:m:msh5|MSH5]]|0.421|
|[[:human genes:g:gosr2|GOSR2]]|0.42|
|[[:human genes:l:lrr1|LRR1]]|0.42|
|[[:human genes:c:cope|COPE]]|0.42|
|[[:human genes:m:mfsd12|MFSD12]]|0.42|
|[[:human genes:a:ahctf1|AHCTF1]]|0.419|
|[[:human genes:s:slc5a5|SLC5A5]]|0.418|
|[[:human genes:m:myo1h|MYO1H]]|0.418|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.418|
|[[:human genes:p:pan3|PAN3]]|0.417|
|[[:human genes:s:sult2b1|SULT2B1]]|0.416|
|[[:human genes:a:atxn1|ATXN1]]|0.414|
|[[:human genes:m:med12|MED12]]|0.414|
|[[:human genes:p:pold1|POLD1]]|0.414|
|[[:human genes:a:atp13a1|ATP13A1]]|0.414|
|[[:human genes:c:cdc6|CDC6]]|0.413|
|[[:human genes:p:pwp2|PWP2]]|0.413|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.412|
|[[:human genes:c:cdca3|CDCA3]]|0.412|
|[[:human genes:p:psmb1|PSMB1]]|0.412|
|[[:human genes:s:snrnp70|SNRNP70]]|0.411|
|[[:human genes:l:lad1|LAD1]]|0.411|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.411|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.411|
|[[:human genes:r:rad21|RAD21]]|0.41|
|[[:human genes:h:hmgcr|HMGCR]]|0.408|
|[[:human genes:a:aqr|AQR]]|0.408|
|[[:human genes:d:ddt|DDT]]|0.408|
|[[:human genes:c:ctage4|CTAGE4]]|0.408|
|[[:human genes:g:golga8o|GOLGA8O]]|0.408|
|[[:human genes:p:psmd2|PSMD2]]|0.408|
|[[:human genes:r:rps10|RPS10]]|0.407|
|[[:human genes:z:znf655|ZNF655]]|0.407|
|[[:human genes:d:dhx38|DHX38]]|0.406|
|[[:human genes:e:exd1|EXD1]]|0.406|
|[[:human genes:r:ranbp2|RANBP2]]|0.406|
|[[:human genes:o:ogfr|OGFR]]|0.406|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.405|
|[[:human genes:r:rrp7a|RRP7A]]|0.404|
|[[:human genes:p:plk1|PLK1]]|0.404|
|[[:human genes:f:fam25b|FAM25B]]|0.404|
|[[:human genes:r:rilpl1|RILPL1]]|0.403|
|[[:human genes:n:nup54|NUP54]]|0.403|
|[[:human genes:a:aprt|APRT]]|0.402|
|[[:human genes:c:cactin|CACTIN]]|0.402|
|[[:human genes:n:nbpf10|NBPF10]]|0.402|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.402|
|[[:human genes:t:twistnb|TWISTNB]]|0.401|
|[[:human genes:p:paf1|PAF1]]|0.401|
|[[:human genes:r:rbm39|RBM39]]|0.401|
|[[:human genes:d:ddx23|DDX23]]|0.401|
|[[:human genes:t:timeless|TIMELESS]]|0.401|
|[[:human genes:n:ndc80|NDC80]]|0.401|
|[[:human genes:p:psap|PSAP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC13 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>