SEC13

Gene Information

Official Symbol: SEC13
Official Name: SEC13 homolog, nuclear pore and COPII coat complex component
Aliases and Previous Symbols: N/A
Entrez ID: 6396
UniProt: P55735
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. {ECO:0000269|PubMed:8972206}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.37
BI-6727 0.04μM R03 exp98	-2.13
42°C R08 exp539	-2.03
Monensin 0.3μM R08 exp507	-1.9
Mitomycin-C 0.06μM R08 exp503	-1.74
GSK461364A 0.005μM R03 exp125	1.71
Nicotinamide Riboside 100μM R03 exp139	1.72
Geldanamycin 0.01μM R05 exp235	1.77
YM155 0.001μM R08 exp432	1.77
Cycloheximide 0.2μM R00 exp15	1.84
Dihydrosphingosine 8μM R08 exp476	1.86
TRAIL 50ng/ml R00 exp36	1.89
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.9
Wortmannin 0.5μM R00 exp37	2.02
BH1 1μM R04 exp169	2.04
Nocodazole 0.02μM R00 exp23	2.04
Beta-Estradiol 0.55μM R07 exp425	2.05
CCT251545 20μM R07 exp326	2.06
Losmapimod 1μM R07 exp376	2.1
Lead acetate 990μM R08 exp496	2.13
UM0011500 10μM R05 exp246	2.14
Hydroxychloroquine 30μM R08 exp490	2.18
Hydroxyurea 15μM R06 exp289	2.44
CCCP 1μM R00 exp11	2.56
GSK-J4 1μM R07 exp362	2.64

Gene	Correlation
DTL	0.567
TBC1D3C	0.539
TBC1D3G	0.536
ATP6V1C1	0.525
PSMB4	0.522
TBC1D3H	0.522
SSH2	0.513
NPIPB5	0.508
ZNF106	0.501
NUP160	0.498
COPG1	0.495
RBBP5	0.491
NUPL1	0.489
ANKLE2	0.489
RPS2	0.488
C1QTNF9B	0.482
RAD51	0.482
DDTL	0.482
CHD4	0.477
TCEB3C	0.477
HIST2H3A	0.476
HIST2H3C	0.476
TCEB3CL	0.475
C14orf93	0.475
DOCK6	0.474
TBC1D3F	0.474
TCEB3CL2	0.474
CBWD5	0.471
SNRPA1	0.468
CBWD3	0.468
SLC6A17	0.468
CCNA2	0.468
POLR2J3	0.467
ORC6	0.465
MED17	0.464
TBC1D3I	0.463
HAP1	0.463
TBC1D3L	0.463
TBC1D3K	0.463
TBC1D3E	0.463
ORC1	0.461
CMYA5	0.46
VASN	0.46
PSMC1	0.459
POLR2D	0.459
EXOSC5	0.459
RRN3	0.457
SUPT5H	0.457
NUP153	0.456
CHAF1A	0.454
CDC45	0.454
HIST1H2BE	0.454
PSMB2	0.454
NUP85	0.453
HIVEP3	0.453
PRPF8	0.452
CDC73	0.452
COPB1	0.452
KCTD17	0.451
HIST2H2BF	0.45
RUVBL2	0.45
SYT9	0.449
SEL1L	0.448
NAPA	0.448
DISP2	0.447
TRIM52	0.447
TBC1D3	0.446
PSMD3	0.446
MYT1L	0.445
FAM160A1	0.445
AKIRIN2	0.445
CTR9	0.445
CBWD6	0.444
PLEKHA4	0.443
RPS14	0.443
VPS54	0.44
RPS12	0.44
ACSF2	0.439
TICRR	0.437
ARCN1	0.437
TSG101	0.437
KIF3C	0.436
NUFIP2	0.436
AAMP	0.436
TFIP11	0.435
MT1E	0.435
POLA1	0.435
PSMD6	0.434
PLA2G4F	0.433
GOLGA6A	0.432
TRAIP	0.432
IGFN1	0.431
SUPT6H	0.431
SAP30BP	0.431
C2orf27B	0.43
CLN6	0.43
ZNF830	0.43
SF3A3	0.429
PSMA6	0.429
SLC4A1	0.429
SNIP1	0.429
PSMD1	0.428
CSNK1A1	0.427
EIF4A3	0.427
PSMC2	0.425
NUP62	0.425
ZFAND5	0.424
C3	0.424
CWC22	0.423
WDR87	0.422
SF3A1	0.422
CCDC64B	0.421
NARFL	0.421
MSH5	0.421
GOSR2	0.42
LRR1	0.42
COPE	0.42
MFSD12	0.42
AHCTF1	0.419
SLC5A5	0.418
MYO1H	0.418
RPS19BP1	0.418
PAN3	0.417
SULT2B1	0.416
ATXN1	0.414
MED12	0.414
POLD1	0.414
ATP13A1	0.414
CDC6	0.413
PWP2	0.413
TP53TG3B	0.412
CDCA3	0.412
PSMB1	0.412
SNRNP70	0.411
LAD1	0.411
TP53TG3C	0.411
TP53TG3	0.411
RAD21	0.41
HMGCR	0.408
AQR	0.408
DDT	0.408
CTAGE4	0.408
GOLGA8O	0.408
PSMD2	0.408
RPS10	0.407
ZNF655	0.407
DHX38	0.406
EXD1	0.406
RANBP2	0.406
OGFR	0.406
DNTTIP2	0.405
RRP7A	0.404
PLK1	0.404
FAM25B	0.404
RILPL1	0.403
NUP54	0.403
APRT	0.402
CACTIN	0.402
NBPF10	0.402
DYNC1I2	0.402
TWISTNB	0.401
PAF1	0.401
RBM39	0.401
DDX23	0.401
TIMELESS	0.401
NDC80	0.401
PSAP	0.4

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	73/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 493
Expression level (log2 read counts): 6.3

Expression Distribution

nuclear pore outer ring
COPII-coated vesicle cargo loading
GATOR2 complex
COPII vesicle coat
positive regulation of TORC1 signaling
protein exit from endoplasmic reticulum
vesicle cargo loading
tRNA export from nucleus
tRNA-containing ribonucleoprotein complex export from nucleus
tRNA transport
ncRNA export from nucleus
regulation of TORC1 signaling
positive regulation of TOR signaling
ER to Golgi transport vesicle membrane
intracellular transport of virus
host cell
transport of virus
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
multi-organism localization
multi-organism transport
Golgi vesicle budding
regulation of glycolytic process
regulation of cellular response to heat
localization within membrane
kinetochore
regulation of gene silencing by miRNA
regulation of carbohydrate catabolic process
vesicle targeting
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
regulation of TOR signaling