SEC16A [The Human Chemical-Genetic Interaction Map Project]

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======= SEC16A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC16A
  * **<color #00a2e8>Official Name</color>**: SEC16 homolog A, endoplasmic reticulum export factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9919|9919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15027|O15027]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC16A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC16A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612854|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec16|
|Sec16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi to plasma membrane CFTR protein transport|
|protein localization to endoplasmic reticulum exit site|
|organelle membrane|
|positive regulation of protein exit from endoplasmic reticulum|
|protein exit from endoplasmic reticulum|
|regulation of protein exit from endoplasmic reticulum|
|endoplasmic reticulum exit site|
|Golgi to plasma membrane protein transport|
|substantia nigra development|
|establishment of protein localization to plasma membrane|
|ER to Golgi transport vesicle membrane|
|endoplasmic reticulum organization|
|Golgi to plasma membrane transport|
|neural nucleus development|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|midbrain development|
|vesicle targeting|
|vesicle-mediated transport to the plasma membrane|
|vesicle budding from membrane|
|post-Golgi vesicle-mediated transport|
|Golgi organization|
|protein localization to endoplasmic reticulum|
|positive regulation of intracellular protein transport|
|establishment of vesicle localization|
|protein stabilization|
|protein localization to plasma membrane|
|vesicle localization|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|response to endoplasmic reticulum stress|
|establishment of protein localization to membrane|
|regulation of protein stability|
|vesicle organization|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|establishment of organelle localization|
|Golgi vesicle transport|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|regulation of cellular protein localization|
|organelle localization|
|Golgi membrane|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|endoplasmic reticulum|
|regulation of protein localization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.44|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.37|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.29|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.29|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.11|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.03|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.91|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.89|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.84|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.82|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.72|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.71|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.77|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.84|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.87|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.89|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.9|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.93|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.06|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.13|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.15|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.2|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.24|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.33|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.58|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uso1|USO1]]|0.464|
|[[:human genes:h:hspd1|HSPD1]]|0.462|
|[[:human genes:a:alg5|ALG5]]|0.462|
|[[:human genes:s:sec31a|SEC31A]]|0.46|
|[[:human genes:g:gfpt1|GFPT1]]|0.459|
|[[:human genes:u:uap1|UAP1]]|0.449|
|[[:human genes:e:eny2|ENY2]]|0.449|
|[[:human genes:p:pmm2|PMM2]]|0.443|
|[[:human genes:d:dpagt1|DPAGT1]]|0.436|
|[[:human genes:h:hars|HARS]]|0.435|
|[[:human genes:t:triap1|TRIAP1]]|0.431|
|[[:human genes:m:mbtps2|MBTPS2]]|0.429|
|[[:human genes:h:hccs|HCCS]]|0.428|
|[[:human genes:n:nxt1|NXT1]]|0.428|
|[[:human genes:c:cycs|CYCS]]|0.427|
|[[:human genes:t:thoc6|THOC6]]|0.425|
|[[:human genes:a:atp5j|ATP5J]]|0.423|
|[[:human genes:a:alg2|ALG2]]|0.42|
|[[:human genes:a:apaf1|APAF1]]|0.419|
|[[:human genes:u:uba3|UBA3]]|0.418|
|[[:human genes:v:vdac2|VDAC2]]|0.417|
|[[:human genes:c:casp9|CASP9]]|0.405|
|[[:human genes:d:dnajc3|DNAJC3]]|0.403|
|[[:human genes:u:ubqln1|UBQLN1]]|0.401|
|[[:human genes:r:rptor|RPTOR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 62/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|5/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC16A Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>