SEC16A

Entrez Summary: N/A
UniProt Summary: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DKK1 89ng/ml R08 exp477	-2.44
B02 10μM R08 exp453	-2.37
Fluvastatin 2.2μM R06 exp282	-2.29
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.29
SGC0649 7μM R03 exp150	-2.11
Cyclosporin-A 0.8μM R07 exp347	-2.03
Cerivastatin 0.15μM R05 exp226	-1.91
YM155 0.0002μM R01 exp61	-1.89
Ibrutinib 10μM R08 exp442	-1.84
Lead acetate 990μM R08 exp496	-1.82
Dihydrosphingosine 8μM R08 exp476	-1.72
Campthothecin 0.001μM R06 exp270	1.71
Daidzin 10μM R06 exp280	1.77
Etoposide 1μM R00 exp19	1.84
Bleomycin 5μM R08 exp459	1.87
TIC10 10μM R08 exp532	1.89
Aminopterin 0.005μM R07 exp335	1.9
Tanespimycin 14μM R08 exp527	1.9
Vinblastine 0.015μM R05 exp208	1.93
UM131593 0.2μM R03 exp106	2.06
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.13
5-Fluorouracil 20μM R00 exp2	2.15
Pimelic-diphenylamide-106 5μM R00 exp28	2.2
Rotenone 20μM R00 exp34	2.24
THZ1 0.06μM R08 exp531	2.33
Etoposide 0.3μM R05 exp199	2.58
CoCl2 18μM R07 exp346	2.74
Doxorubicin 0.02μM R08 exp478	2.81

Global Fraction of Cell Lines Where Essential: 62/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	5/26
breast	2/33
central nervous system	2/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	2/20
lung	6/75
lymphocyte	3/16
ovary	5/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Expression Distribution

Sec16
Sec16 C

Golgi to plasma membrane CFTR protein transport
protein localization to endoplasmic reticulum exit site
organelle membrane
positive regulation of protein exit from endoplasmic reticulum
protein exit from endoplasmic reticulum
regulation of protein exit from endoplasmic reticulum
endoplasmic reticulum exit site
Golgi to plasma membrane protein transport
substantia nigra development
establishment of protein localization to plasma membrane
ER to Golgi transport vesicle membrane
endoplasmic reticulum organization
Golgi to plasma membrane transport
neural nucleus development
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
midbrain development
vesicle targeting
vesicle-mediated transport to the plasma membrane
vesicle budding from membrane
post-Golgi vesicle-mediated transport
Golgi organization
protein localization to endoplasmic reticulum
positive regulation of intracellular protein transport
establishment of vesicle localization
protein stabilization
protein localization to plasma membrane
vesicle localization
positive regulation of intracellular transport
endoplasmic reticulum to Golgi vesicle-mediated transport
protein localization to cell periphery
regulation of intracellular protein transport
response to endoplasmic reticulum stress
establishment of protein localization to membrane
regulation of protein stability
vesicle organization