SEC61A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SEC61A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC61A1
  * **<color #00a2e8>Official Name</color>**: SEC61 translocon subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29927|29927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61619|P61619]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC61A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC61A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SecY|
|Plug translocon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pronephric nephron development|
|signal sequence binding|
|Sec61 translocon complex|
|posttranslational protein targeting to membrane, translocation|
|SRP-dependent cotranslational protein targeting to membrane, translocation|
|pronephros development|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|protein transmembrane transporter activity|
|intracellular protein transmembrane transport|
|calcium channel activity|
|endoplasmic reticulum organization|
|ribosome binding|
|protein transmembrane transport|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|integral component of endoplasmic reticulum membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|nephron development|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|response to interferon-gamma|
|calcium ion transmembrane transport|
|calcium ion transport|
|establishment of protein localization to membrane|
|kidney development|
|renal system development|
|divalent metal ion transport|
|divalent inorganic cation transport|
|urogenital system development|
|protein targeting|
|endomembrane system organization|
|establishment of protein localization to organelle|
|protein localization to membrane|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein localization to organelle|
|innate immune response|
|cation transport|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|defense response to other organism|
|intracellular protein transport|
|endoplasmic reticulum|
|response to cytokine|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.19|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 731/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC61A1 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>