SEC61A1

Entrez Summary: The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 731/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	73/75
lymphocyte	15/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

Screen	Score
Golgicide-A 4μM R03 exp122	-2.19
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.84

SecY
Plug translocon

pronephric nephron development
signal sequence binding
Sec61 translocon complex
posttranslational protein targeting to membrane, translocation
SRP-dependent cotranslational protein targeting to membrane, translocation
pronephros development
posttranslational protein targeting to endoplasmic reticulum membrane
protein transmembrane transporter activity
intracellular protein transmembrane transport
calcium channel activity
endoplasmic reticulum organization
ribosome binding
protein transmembrane transport
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
integral component of endoplasmic reticulum membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
nephron development
protein localization to endoplasmic reticulum
protein targeting to membrane
response to interferon-gamma
calcium ion transmembrane transport
calcium ion transport
establishment of protein localization to membrane
kidney development
renal system development
divalent metal ion transport
divalent inorganic cation transport
urogenital system development
protein targeting
endomembrane system organization
establishment of protein localization to organelle
protein localization to membrane
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
protein localization to organelle
innate immune response