SEC61A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SEC61A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC61A2
  * **<color #00a2e8>Official Name</color>**: SEC61 translocon subunit alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55176|55176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9S3|Q9H9S3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC61A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC61A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618271|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SecY|
|Plug translocon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal sequence binding|
|Sec61 translocon complex|
|SRP-dependent cotranslational protein targeting to membrane, translocation|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|protein transmembrane transporter activity|
|intracellular protein transmembrane transport|
|ribosome binding|
|protein transmembrane transport|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|molecular function|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.4|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.22|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.13|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.03|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.96|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.89|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.8|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.74|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.73|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.87|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.9|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.491|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC61A2 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>