SEC61A2

Entrez Summary: N/A
UniProt Summary: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 8μM R07 exp333	-2.4
Tenofovir 10μM R07 exp405	-2.22
TRAIL 50ng/ml R00 exp36	-2.13
I-BRD9 4μM R07 exp365	-2.03
BI-D1870 3.15μM R02 exp66	-1.96
Rifampicin 1μM R00 exp31	-1.89
BS-181 20μM R08 exp461	-1.81
BRD2 inhibitor II 20μM R07 exp341	-1.8
Rapamycin 1μM R00 exp29	-1.74
Benzoate 10000μM R08 exp455	-1.73
5-Azacytidine 2μM R07 exp330	-1.72
Bleomycin 5μM R08 exp459	1.87
ML-792 0.2μM R08 exp505	1.9
Vitamin-D3 40μM R08 exp536	1.92

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SecY
Plug translocon

signal sequence binding
Sec61 translocon complex
SRP-dependent cotranslational protein targeting to membrane, translocation
posttranslational protein targeting to endoplasmic reticulum membrane
protein transmembrane transporter activity
intracellular protein transmembrane transport
ribosome binding
protein transmembrane transport
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
molecular function
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport