SEH1L [The Human Chemical-Genetic Interaction Map Project]

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======= SEH1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEH1L
  * **<color #00a2e8>Official Name</color>**: SEH1 like nucleoporin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81929|81929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EE3|Q96EE3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEH1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEH1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609263|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Seh1-associated complex|
|cytokine production involved in inflammatory response|
|nuclear pore outer ring|
|attachment of mitotic spindle microtubules to kinetochore|
|GATOR2 complex|
|nuclear pore organization|
|positive regulation of TORC1 signaling|
|production of molecular mediator involved in inflammatory response|
|attachment of spindle microtubules to kinetochore|
|cellular protein-containing complex localization|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|mitotic metaphase plate congression|
|intracellular transport of virus|
|metaphase plate congression|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|establishment of chromosome localization|
|chromosome localization|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|condensed chromosome kinetochore|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|defense response to Gram-positive bacterium|
|regulation of TOR signaling|
|mRNA export from nucleus|
|mitotic sister chromatid segregation|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|sister chromatid segregation|
|mitotic nuclear division|
|protein export from nucleus|
|cytokine production|
|cellular response to starvation|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|nuclear envelope|
|structural molecule activity|
|RNA transport|
|nucleic acid transport|
|response to starvation|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear chromosome segregation|
|cellular response to nutrient levels|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|cellular response to extracellular stimulus|
|nuclear transport|
|chromosome segregation|
|nuclear division|
|lysosomal membrane|
|organelle fission|
|peptidyl-lysine modification|
|defense response to bacterium|
|cellular response to external stimulus|
|establishment of organelle localization|
|regulation of small molecule metabolic process|
|cell division|
|inflammatory response|
|response to nutrient levels|
|response to extracellular stimulus|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|response to bacterium|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|chromosome organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.77|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.78|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.9|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.06|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.567|
|[[:human genes:r:rptor|RPTOR]]|0.528|
|[[:human genes:h:hspd1|HSPD1]]|0.527|
|[[:human genes:g:gmppb|GMPPB]]|0.504|
|[[:human genes:r:rnmt|RNMT]]|0.502|
|[[:human genes:m:meaf6|MEAF6]]|0.501|
|[[:human genes:c:cct7|CCT7]]|0.5|
|[[:human genes:a:aars|AARS]]|0.486|
|[[:human genes:s:smarcd1|SMARCD1]]|0.482|
|[[:human genes:c:csnk2b|CSNK2B]]|0.481|
|[[:human genes:n:nae1|NAE1]]|0.481|
|[[:human genes:w:wdr24|WDR24]]|0.481|
|[[:human genes:r:rtcb|RTCB]]|0.479|
|[[:human genes:n:nars|NARS]]|0.473|
|[[:human genes:g:gnb1l|GNB1L]]|0.473|
|[[:human genes:t:telo2|TELO2]]|0.471|
|[[:human genes:t:tti1|TTI1]]|0.471|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.469|
|[[:human genes:m:mars|MARS]]|0.468|
|[[:human genes:m:med16|MED16]]|0.467|
|[[:human genes:e:eprs|EPRS]]|0.466|
|[[:human genes:m:mtor|MTOR]]|0.458|
|[[:human genes:e:eif4e|EIF4E]]|0.457|
|[[:human genes:s:spcs2|SPCS2]]|0.456|
|[[:human genes:t:thg1l|THG1L]]|0.456|
|[[:human genes:p:pelo|PELO]]|0.453|
|[[:human genes:e:eny2|ENY2]]|0.452|
|[[:human genes:t:tti2|TTI2]]|0.451|
|[[:human genes:t:tbcd|TBCD]]|0.439|
|[[:human genes:c:ccdc101|CCDC101]]|0.439|
|[[:human genes:p:pax5|PAX5]]|0.437|
|[[:human genes:t:tle4|TLE4]]|0.434|
|[[:human genes:r:rad1|RAD1]]|0.428|
|[[:human genes:g:gfpt1|GFPT1]]|0.428|
|[[:human genes:f:faf2|FAF2]]|0.421|
|[[:human genes:c:cars|CARS]]|0.42|
|[[:human genes:a:alg1|ALG1]]|0.42|
|[[:human genes:p:plaa|PLAA]]|0.419|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.416|
|[[:human genes:t:thoc3|THOC3]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.412|
|[[:human genes:z:znf259|ZNF259]]|0.412|
|[[:human genes:w:wdr59|WDR59]]|0.409|
|[[:human genes:y:yars|YARS]]|0.403|
|[[:human genes:d:dpagt1|DPAGT1]]|0.402|
|[[:human genes:n:nup50|NUP50]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 586/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|24/28|
|bone|25/26|
|breast|28/33|
|central nervous system|51/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|18/21|
|liver|14/20|
|lung|54/75|
|lymphocyte|15/16|
|ovary|20/26|
|pancreas|22/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|22/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1162
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEH1L Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>