SEH1L
Gene Information
- Official Symbol: SEH1L
- Official Name: SEH1 like nucleoporin
- Aliases and Previous Symbols: N/A
- Entrez ID: 81929
- UniProt: Q96EE3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
GO Terms
| Seh1-associated complex |
| cytokine production involved in inflammatory response |
| nuclear pore outer ring |
| attachment of mitotic spindle microtubules to kinetochore |
| GATOR2 complex |
| nuclear pore organization |
| positive regulation of TORC1 signaling |
| production of molecular mediator involved in inflammatory response |
| attachment of spindle microtubules to kinetochore |
| cellular protein-containing complex localization |
| tRNA export from nucleus |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| regulation of TORC1 signaling |
| positive regulation of TOR signaling |
| cellular response to amino acid starvation |
| response to amino acid starvation |
| mitotic metaphase plate congression |
| intracellular transport of virus |
| metaphase plate congression |
| host cell |
| transport of virus |
| protein sumoylation |
| multi-organism transport |
| multi-organism localization |
| establishment of chromosome localization |
| chromosome localization |
| regulation of glycolytic process |
| regulation of cellular response to heat |
| kinetochore |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| condensed chromosome kinetochore |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| defense response to Gram-positive bacterium |
| regulation of TOR signaling |
| mRNA export from nucleus |
| mitotic sister chromatid segregation |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| viral transcription |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| regulation of gene silencing |
| viral gene expression |
| nucleus organization |
| sister chromatid segregation |
| mitotic nuclear division |
| protein export from nucleus |
| cytokine production |
| cellular response to starvation |
| mRNA transport |
| nuclear export |
| regulation of generation of precursor metabolites and energy |
| nuclear envelope |
| structural molecule activity |
| RNA transport |
| nucleic acid transport |
| response to starvation |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| nuclear chromosome segregation |
| cellular response to nutrient levels |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| cellular response to extracellular stimulus |
| nuclear transport |
| chromosome segregation |
| nuclear division |
| lysosomal membrane |
| organelle fission |
| peptidyl-lysine modification |
| defense response to bacterium |
| cellular response to external stimulus |
| establishment of organelle localization |
| regulation of small molecule metabolic process |
| cell division |
| inflammatory response |
| response to nutrient levels |
| response to extracellular stimulus |
| organelle localization |
| mitotic cell cycle process |
| mitotic cell cycle |
| response to bacterium |
| viral process |
| regulation of cellular response to stress |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| peptidyl-amino acid modification |
| defense response to other organism |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| cell cycle process |
| positive regulation of intracellular signal transduction |
| chromosome organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| cell cycle |
| defense response |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of signal transduction |
| cellular response to stress |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.567 |
| RPTOR | 0.528 |
| HSPD1 | 0.527 |
| GMPPB | 0.504 |
| RNMT | 0.502 |
| MEAF6 | 0.501 |
| CCT7 | 0.5 |
| AARS | 0.486 |
| SMARCD1 | 0.482 |
| CSNK2B | 0.481 |
| NAE1 | 0.481 |
| WDR24 | 0.481 |
| RTCB | 0.479 |
| NARS | 0.473 |
| GNB1L | 0.473 |
| TELO2 | 0.471 |
| TTI1 | 0.471 |
| LAMTOR5 | 0.469 |
| MARS | 0.468 |
| MED16 | 0.467 |
| EPRS | 0.466 |
| MTOR | 0.458 |
| EIF4E | 0.457 |
| SPCS2 | 0.456 |
| THG1L | 0.456 |
| PELO | 0.453 |
| ENY2 | 0.452 |
| TTI2 | 0.451 |
| TBCD | 0.439 |
| CCDC101 | 0.439 |
| PAX5 | 0.437 |
| TLE4 | 0.434 |
| RAD1 | 0.428 |
| GFPT1 | 0.428 |
| FAF2 | 0.421 |
| CARS | 0.42 |
| ALG1 | 0.42 |
| PLAA | 0.419 |
| GTF3C2 | 0.416 |
| THOC3 | 0.415 |
| ADSL | 0.412 |
| ZNF259 | 0.412 |
| WDR59 | 0.409 |
| YARS | 0.403 |
| DPAGT1 | 0.402 |
| NUP50 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 586/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 24/28 |
| blood | 24/28 |
| bone | 25/26 |
| breast | 28/33 |
| central nervous system | 51/56 |
| cervix | 3/4 |
| colorectal | 14/17 |
| esophagus | 8/13 |
| fibroblast | 0/1 |
| gastric | 9/16 |
| kidney | 18/21 |
| liver | 14/20 |
| lung | 54/75 |
| lymphocyte | 15/16 |
| ovary | 20/26 |
| pancreas | 22/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 13/15 |
| prostate | 0/1 |
| skin | 17/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 22/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 1162
- Expression level (log2 read counts): 6.96
Expression Distribution
SEH1L Expression in NALM6 Cells: 6.96
