SELK

Gene Information

Official Symbol: SELENOK
Official Name: selenoprotein K
Aliases and Previous Symbols: N/A
Entrez ID: 58515
UniProt: Q9Y6D0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588). {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385, ECO:0000269|PubMed:25368151}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10728
Expression level (log2 read counts): 4.87

Expression Distribution

Screen	Score
IWR1 50μM R08 exp495	-1.74
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.7

respiratory burst after phagocytosis
foam cell differentiation
respiratory burst involved in defense response
macrophage derived foam cell differentiation
positive regulation of monocyte chemotactic protein-1 production
positive regulation of chemokine secretion
regulation of chemokine secretion
regulation of monocyte chemotactic protein-1 production
respiratory burst
endoplasmic reticulum calcium ion homeostasis
positive regulation of defense response to virus by host
positive regulation of T cell migration
positive regulation of interleukin-6 secretion
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein palmitoylation
positive regulation of lymphocyte migration
regulation of defense response to virus by host
regulation of T cell migration
positive regulation of chemokine production
regulation of lymphocyte migration
regulation of defense response to virus
regulation of chemokine production
positive regulation of tumor necrosis factor production
protein lipidation
positive regulation of tumor necrosis factor superfamily cytokine production
lipoprotein biosynthetic process
positive regulation of interleukin-6 production
positive regulation of T cell proliferation
regulation of calcium-mediated signaling
lipoprotein metabolic process
positive regulation of leukocyte migration
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
positive regulation of cytokine secretion
regulation of interleukin-6 production
regulation of tumor necrosis factor production
intrinsic apoptotic signaling pathway
regulation of tumor necrosis factor superfamily cytokine production
regulation of T cell proliferation