SELP [The Human Chemical-Genetic Interaction Map Project]

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======= SELP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SELP
  * **<color #00a2e8>Official Name</color>**: selectin P
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6403|6403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16109|P16109]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SELP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SELP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:7585950}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycosphingolipid binding|
|fucose binding|
|positive regulation of platelet activation|
|platelet dense granule membrane|
|oligosaccharide binding|
|sialic acid binding|
|regulation of integrin activation|
|platelet alpha granule membrane|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|calcium-mediated signaling using intracellular calcium source|
|positive regulation of blood coagulation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|regulation of platelet activation|
|lipopolysaccharide binding|
|cellular extravasation|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|leukocyte cell-cell adhesion|
|positive regulation of wound healing|
|calcium-dependent protein binding|
|positive regulation of response to wounding|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|defense response to Gram-negative bacterium|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of leukocyte migration|
|platelet degranulation|
|regulation of wound healing|
|calcium-mediated signaling|
|regulation of response to wounding|
|heparin binding|
|regulation of leukocyte migration|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|second-messenger-mediated signaling|
|leukocyte migration|
|external side of plasma membrane|
|positive regulation of cell activation|
|regulation of protein complex assembly|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of cell activation|
|response to bacterium|
|regulated exocytosis|
|calcium ion binding|
|exocytosis|
|regulation of cell migration|
|response to lipid|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|export from cell|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.478|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SELP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>