SELP

Entrez Summary: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008].
UniProt Summary: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:28011641, ECO:0000269|PubMed:7585950}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lectin C
Sushi

glycosphingolipid binding
fucose binding
positive regulation of platelet activation
platelet dense granule membrane
oligosaccharide binding
sialic acid binding
regulation of integrin activation
platelet alpha granule membrane
leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
calcium-mediated signaling using intracellular calcium source
positive regulation of blood coagulation
positive regulation of hemostasis
positive regulation of coagulation
regulation of platelet activation
lipopolysaccharide binding
cellular extravasation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
positive regulation of wound healing
calcium-dependent protein binding
positive regulation of response to wounding
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
defense response to Gram-negative bacterium
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of leukocyte migration
platelet degranulation
regulation of wound healing
calcium-mediated signaling
regulation of response to wounding
heparin binding
regulation of leukocyte migration
cell-cell adhesion via plasma-membrane adhesion molecules
response to lipopolysaccharide
response to molecule of bacterial origin
defense response to bacterium