SELPLG

Entrez Summary: N/A
UniProt Summary: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leukocyte adhesive activation
uropod
leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
plasma membrane raft
cellular response to interleukin-6
response to interleukin-6
cellular extravasation
leukocyte cell-cell adhesion
virus receptor activity
viral entry into host cell
entry into host cell
entry into host
interaction with host
viral life cycle
signaling receptor binding
leukocyte migration
cell-cell adhesion
viral process
symbiotic process
interspecies interaction between organisms
leukocyte activation
cell adhesion
biological adhesion
cell migration
cellular response to cytokine stimulus
cell activation
cell motility
localization of cell
response to cytokine
locomotion
integral component of plasma membrane
movement of cell or subcellular component
membrane