SEMA3A [The Human Chemical-Genetic Interaction Map Project]

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======= SEMA3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA3A
  * **<color #00a2e8>Official Name</color>**: semaphorin 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10371|10371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14563|Q14563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. {ECO:0000269|PubMed:22416012}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neural crest cell migration involved in sympathetic nervous system development|
|facioacoustic ganglion development|
|cerebral cortex tangential migration using cell-axon interactions|
|hypothalamic tangential migration using cell-axon interactions|
|basal dendrite morphogenesis|
|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|
|basal dendrite development|
|basal dendrite arborization|
|hypothalamus gonadotrophin-releasing hormone neuron differentiation|
|ventral trunk neural crest cell migration|
|trunk neural crest cell migration|
|hypothalamus cell migration|
|sympathetic neuron projection guidance|
|sympathetic neuron projection extension|
|hypothalamus gonadotrophin-releasing hormone neuron development|
|trunk segmentation|
|trigeminal ganglion development|
|trigeminal nerve structural organization|
|trigeminal nerve morphogenesis|
|dichotomous subdivision of terminal units involved in salivary gland branching|
|substrate-dependent cerebral cortex tangential migration|
|axonogenesis involved in innervation|
|neural crest cell migration involved in autonomic nervous system development|
|branchiomotor neuron axon guidance|
|cranial ganglion development|
|dendrite arborization|
|positive regulation of male gonad development|
|neuron projection extension involved in neuron projection guidance|
|axon extension involved in axon guidance|
|hypothalamus cell differentiation|
|sympathetic ganglion development|
|facial nerve structural organization|
|regulation of male gonad development|
|cerebral cortex tangential migration|
|dichotomous subdivision of an epithelial terminal unit|
|neuron projection arborization|
|facial nerve morphogenesis|
|cranial nerve structural organization|
|positive regulation of gonad development|
|facial nerve development|
|trigeminal nerve development|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|ganglion development|
|positive regulation of neuron migration|
|branching involved in salivary gland morphogenesis|
|anatomical structure arrangement|
|preganglionic parasympathetic fiber development|
|neuropilin binding|
|parasympathetic nervous system development|
|regulation of gonad development|
|blastoderm segmentation|
|sympathetic nervous system development|
|hypothalamus development|
|axonal fasciculation|
|neuron projection fasciculation|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|substrate-dependent cell migration|
|innervation|
|negative regulation of axon guidance|
|motor neuron axon guidance|
|cranial nerve morphogenesis|
|salivary gland morphogenesis|
|forebrain neuron development|
|salivary gland development|
|regulation of axon extension involved in axon guidance|
|olfactory bulb development|
|olfactory lobe development|
|axon extension|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|regulation of neuron migration|
|cerebral cortex cell migration|
|exocrine system development|
|regulation of axon guidance|
|negative chemotaxis|
|autonomic nervous system development|
|neuron recognition|
|forebrain neuron differentiation|
|cranial nerve development|
|neural crest cell migration|
|negative regulation of chemotaxis|
|telencephalon cell migration|
|dendrite morphogenesis|
|neuron projection extension|
|forebrain cell migration|
|embryonic pattern specification|
|forebrain generation of neurons|
|negative regulation of epithelial cell migration|
|negative regulation of axonogenesis|
|diencephalon development|
|positive regulation of reproductive process|
|nerve development|
|neural crest cell development|
|central nervous system neuron development|
|stem cell development|
|mesenchymal cell development|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|segmentation|
|regulation of heart rate|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|gland morphogenesis|
|dendrite development|
|negative regulation of developmental growth|
|limbic system development|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|neuron migration|
|positive regulation of JNK cascade|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|regulation of reproductive process|
|positive regulation of stress-activated MAPK cascade|
|morphogenesis of a branching structure|
|positive regulation of stress-activated protein kinase signaling cascade|
|ameboidal-type cell migration|
|pallium development|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of JNK cascade|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cell recognition|
|regulation of heart contraction|
|negative regulation of growth|
|telencephalon development|
|negative regulation of cell migration|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell motility|
|regulation of blood circulation|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|sensory system development|
|axonogenesis|
|regulation of cellular component size|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|gland development|
|regulation of cell growth|
|dendrite|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|regulation of system process|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA3A Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>