SEMA3A

Gene Information

Official Symbol: SEMA3A
Official Name: semaphorin 3A
Aliases and Previous Symbols: N/A
Entrez ID: 10371
UniProt: Q14563
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. {ECO:0000269|PubMed:22416012}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18128
Expression level (log2 read counts): -2.08

Expression Distribution

neural crest cell migration involved in sympathetic nervous system development
facioacoustic ganglion development
cerebral cortex tangential migration using cell-axon interactions
hypothalamic tangential migration using cell-axon interactions
basal dendrite morphogenesis
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
basal dendrite development
basal dendrite arborization
hypothalamus gonadotrophin-releasing hormone neuron differentiation
ventral trunk neural crest cell migration
trunk neural crest cell migration
hypothalamus cell migration
sympathetic neuron projection guidance
sympathetic neuron projection extension
hypothalamus gonadotrophin-releasing hormone neuron development
trunk segmentation
trigeminal ganglion development
trigeminal nerve structural organization
trigeminal nerve morphogenesis
dichotomous subdivision of terminal units involved in salivary gland branching
substrate-dependent cerebral cortex tangential migration
axonogenesis involved in innervation
neural crest cell migration involved in autonomic nervous system development
branchiomotor neuron axon guidance
cranial ganglion development
dendrite arborization
positive regulation of male gonad development
neuron projection extension involved in neuron projection guidance
axon extension involved in axon guidance
hypothalamus cell differentiation
sympathetic ganglion development
facial nerve structural organization
regulation of male gonad development
cerebral cortex tangential migration
dichotomous subdivision of an epithelial terminal unit
neuron projection arborization
facial nerve morphogenesis
cranial nerve structural organization
positive regulation of gonad development
facial nerve development