SEMA3F [The Human Chemical-Genetic Interaction Map Project]

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======= SEMA3F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA3F
  * **<color #00a2e8>Official Name</color>**: semaphorin 3F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6405|6405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13275|Q13275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA3F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA3F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cell motility and cell adhesion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trunk neural crest cell migration|
|ventral trunk neural crest cell migration|
|sympathetic neuron projection guidance|
|trunk segmentation|
|sympathetic neuron projection extension|
|trigeminal nerve morphogenesis|
|trigeminal nerve structural organization|
|branchiomotor neuron axon guidance|
|neural crest cell migration involved in autonomic nervous system development|
|axon extension involved in axon guidance|
|neuron projection extension involved in neuron projection guidance|
|facial nerve structural organization|
|sympathetic ganglion development|
|cranial nerve structural organization|
|facial nerve development|
|facial nerve morphogenesis|
|semaphorin-plexin signaling pathway involved in axon guidance|
|trigeminal nerve development|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|ganglion development|
|anatomical structure arrangement|
|preganglionic parasympathetic fiber development|
|blastoderm segmentation|
|parasympathetic nervous system development|
|neuropilin binding|
|sympathetic nervous system development|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|negative regulation of axon guidance|
|motor neuron axon guidance|
|cranial nerve morphogenesis|
|regulation of axon extension involved in axon guidance|
|axon extension|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|autonomic nervous system development|
|cranial nerve development|
|neural crest cell migration|
|negative regulation of chemotaxis|
|neuron projection extension|
|embryonic pattern specification|
|negative regulation of axonogenesis|
|nerve development|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|segmentation|
|regulation of axon extension|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|ameboidal-type cell migration|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of chemotaxis|
|regulation of synapse organization|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|negative regulation of growth|
|axon guidance|
|neuron projection guidance|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|glutamatergic synapse|
|negative regulation of response to external stimulus|
|axonogenesis|
|regulation of cellular component size|
|developmental growth|
|growth|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.37|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.79|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.79|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.82|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.82|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14454
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA3F Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>