SEMA3F
Gene Information
- Official Symbol: SEMA3F
- Official Name: semaphorin 3F
- Aliases and Previous Symbols: N/A
- Entrez ID: 6405
- UniProt: Q13275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in cell motility and cell adhesion.
Pfam Domains GO Terms
Pfam Domains
| Sema |
GO Terms
| trunk neural crest cell migration |
| ventral trunk neural crest cell migration |
| sympathetic neuron projection guidance |
| trunk segmentation |
| sympathetic neuron projection extension |
| trigeminal nerve morphogenesis |
| trigeminal nerve structural organization |
| branchiomotor neuron axon guidance |
| neural crest cell migration involved in autonomic nervous system development |
| axon extension involved in axon guidance |
| neuron projection extension involved in neuron projection guidance |
| facial nerve structural organization |
| sympathetic ganglion development |
| cranial nerve structural organization |
| facial nerve development |
| facial nerve morphogenesis |
| semaphorin-plexin signaling pathway involved in axon guidance |
| trigeminal nerve development |
| semaphorin-plexin signaling pathway involved in neuron projection guidance |
| ganglion development |
| anatomical structure arrangement |
| preganglionic parasympathetic fiber development |
| blastoderm segmentation |
| parasympathetic nervous system development |
| neuropilin binding |
| sympathetic nervous system development |
| semaphorin receptor binding |
| negative regulation of axon extension involved in axon guidance |
| chemorepellent activity |
| negative regulation of axon guidance |
| motor neuron axon guidance |
| cranial nerve morphogenesis |
| regulation of axon extension involved in axon guidance |
| axon extension |
| semaphorin-plexin signaling pathway |
| negative regulation of axon extension |
| regulation of axon guidance |
| negative chemotaxis |
| autonomic nervous system development |
| cranial nerve development |
| neural crest cell migration |
| negative regulation of chemotaxis |
| neuron projection extension |
| embryonic pattern specification |
| negative regulation of axonogenesis |
| nerve development |
| neural crest cell development |
| mesenchymal cell development |
| stem cell development |
| developmental cell growth |
| neural crest cell differentiation |
| cell growth |
| segmentation |
| regulation of axon extension |
| regulation of postsynapse organization |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| developmental growth involved in morphogenesis |
| negative regulation of neuron projection development |
| mesenchymal cell differentiation |
| stem cell differentiation |
| ameboidal-type cell migration |
| regulation of cell size |
| negative regulation of cell projection organization |
| negative regulation of cell growth |
| regulation of axonogenesis |
| regulation of chemotaxis |
| regulation of synapse organization |
| mesenchyme development |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| negative regulation of growth |
| axon guidance |
| neuron projection guidance |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| regulation of developmental growth |
| regionalization |
| negative regulation of cell development |
| glutamatergic synapse |
| negative regulation of response to external stimulus |
| axonogenesis |
| regulation of cellular component size |
| developmental growth |
| growth |
| axon development |
| regulation of cell growth |
| cell morphogenesis involved in neuron differentiation |
| pattern specification process |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cell part morphogenesis |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cell morphogenesis involved in differentiation |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| locomotion |
| integral component of plasma membrane |
| generation of neurons |
| movement of cell or subcellular component |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| tissue development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 1000μM R03 exp101 | -2.37 |
| Nifurtimox 1μM R03 exp141 | -1.79 |
| UMK57 0.6μM R03 exp107 | -1.79 |
| CHIR-124 0.04μM R06 exp272 | 1.82 |
| Rotenone 0.07μM R08 exp431 | 1.82 |
| Myriocin 25μM R06 exp293 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14454
- Expression level (log2 read counts): 2.05
Expression Distribution
SEMA3F Expression in NALM6 Cells: 2.05
