SEMA4G
Gene Information
- Official Symbol: SEMA4G
- Official Name: semaphorin 4G
- Aliases and Previous Symbols: N/A
- Entrez ID: 57715
- UniProt: Q9NTN9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Sema |
| PSI |
GO Terms
| neuropilin binding |
| semaphorin receptor binding |
| negative regulation of axon extension involved in axon guidance |
| chemorepellent activity |
| negative regulation of axon guidance |
| regulation of axon extension involved in axon guidance |
| semaphorin-plexin signaling pathway |
| negative regulation of axon extension |
| regulation of axon guidance |
| negative chemotaxis |
| neural crest cell migration |
| negative regulation of chemotaxis |
| negative regulation of axonogenesis |
| neural crest cell development |
| stem cell development |
| mesenchymal cell development |
| neural crest cell differentiation |
| regulation of axon extension |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| negative regulation of neuron projection development |
| mesenchymal cell differentiation |
| stem cell differentiation |
| ameboidal-type cell migration |
| regulation of cell size |
| negative regulation of cell projection organization |
| negative regulation of cell growth |
| regulation of axonogenesis |
| regulation of chemotaxis |
| mesenchyme development |
| negative regulation of neuron differentiation |
| negative regulation of growth |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| regulation of developmental growth |
| negative regulation of cell development |
| negative regulation of response to external stimulus |
| regulation of cellular component size |
| regulation of cell growth |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| negative regulation of multicellular organismal process |
| locomotion |
| integral component of plasma membrane |
| generation of neurons |
| movement of cell or subcellular component |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| tissue development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11787
- Expression level (log2 read counts): 2.7
Expression Distribution
SEMA4G Expression in NALM6 Cells: 2.7
