SEPP1

Entrez Summary: N/A
UniProt Summary: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	1.73
NN-Dimethylsphingosine 2.5μM R08 exp508	1.78

SelP C
SelP N

selenium compound metabolic process
selenium binding
response to selenium ion
platelet dense granule lumen
post-embryonic development
platelet degranulation
locomotory behavior
response to oxidative stress
response to inorganic substance
behavior
regulation of growth
regulated exocytosis
brain development
head development
exocytosis
sexual reproduction
central nervous system development
multi-organism reproductive process
secretion by cell
export from cell
secretion
reproductive process
reproduction
extracellular space
extracellular region
vesicle-mediated transport