SEPT4 [The Human Chemical-Genetic Interaction Map Project]

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======= SEPT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEPTIN4
  * **<color #00a2e8>Official Name</color>**: septin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5414|5414]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43236|O43236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEPT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEPT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603696|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. {ECO:0000250, ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15837787, ECO:0000269|PubMed:9889007, ECO:0000305, ECO:0000305|PubMed:25588830}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Septin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm mitochondrion organization|
|sperm annulus|
|septin ring|
|septin complex|
|sperm capacitation|
|positive regulation of intrinsic apoptotic signaling pathway|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of protein ubiquitination|
|synaptic vesicle|
|positive regulation of protein modification by small protein conjugation or removal|
|spermatid development|
|microtubule cytoskeleton|
|spermatid differentiation|
|cell maturation|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|positive regulation of apoptotic signaling pathway|
|structural molecule activity|
|regulation of protein ubiquitination|
|magnesium ion binding|
|regulation of exocytosis|
|regulation of protein modification by small protein conjugation or removal|
|developmental maturation|
|germ cell development|
|GTPase activity|
|protein homooligomerization|
|cellular process involved in reproduction in multicellular organism|
|GTP binding|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|cell division|
|protein complex oligomerization|
|spermatogenesis|
|regulation of vesicle-mediated transport|
|male gamete generation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|gamete generation|
|positive regulation of cell death|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|apoptotic process|
|central nervous system development|
|multi-organism reproductive process|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|positive regulation of protein modification process|
|mitochondrion|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.9|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10330
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEPT4 Expression in NALM6 Cells: 1.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>