SEPT4

Entrez Summary: N/A
UniProt Summary: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. {ECO:0000250, ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15837787, ECO:0000269|PubMed:9889007, ECO:0000305, ECO:0000305|PubMed:25588830}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Deguelin 0.05μM R02 exp69	1.9
Temozolomide 200μM R04 exp189	2.24

sperm mitochondrion organization
sperm annulus
septin ring
septin complex
sperm capacitation
positive regulation of intrinsic apoptotic signaling pathway
cytoskeleton-dependent cytokinesis
cytokinesis
positive regulation of protein ubiquitination
synaptic vesicle
positive regulation of protein modification by small protein conjugation or removal
spermatid development
microtubule cytoskeleton
spermatid differentiation
cell maturation
regulation of intrinsic apoptotic signaling pathway
mitochondrial outer membrane
positive regulation of apoptotic signaling pathway
structural molecule activity
regulation of protein ubiquitination
magnesium ion binding
regulation of exocytosis
regulation of protein modification by small protein conjugation or removal
developmental maturation
germ cell development
GTPase activity
protein homooligomerization
cellular process involved in reproduction in multicellular organism
GTP binding
regulation of apoptotic signaling pathway
mitochondrion organization
cell division
protein complex oligomerization
spermatogenesis
regulation of vesicle-mediated transport
male gamete generation
positive regulation of apoptotic process
positive regulation of programmed cell death
developmental process involved in reproduction
gamete generation