SERBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SERBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERBP1
  * **<color #00a2e8>Official Name</color>**: SERPINE1 mRNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26135|26135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NC51|Q8NC51]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607378|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HABP4 PAI-RBP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PML body organization|
|SUMO binding|
|nuclear body organization|
|mRNA 3-UTR binding|
|nucleus organization|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|cadherin binding|
|regulation of mRNA metabolic process|
|posttranscriptional regulation of gene expression|
|perinuclear region of cytoplasm|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.78|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.78|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.14|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.24|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|4.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.531|
|[[:human genes:g:gcn1l1|GCN1L1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2020
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERBP1 Expression in NALM6 Cells: 9.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>