SERINC5

Entrez Summary: N/A
UniProt Summary: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q63175, ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
positive regulation of serine C-palmitoyltransferase activity
regulation of serine C-palmitoyltransferase activity
detection of virus
L-serine biosynthetic process
L-serine metabolic process
serine family amino acid biosynthetic process
phosphatidylserine metabolic process
myelin sheath
serine family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
myelination
axon ensheathment
ensheathment of neurons
sphingolipid metabolic process
defense response to virus
cellular modified amino acid metabolic process
membrane lipid metabolic process
alpha-amino acid metabolic process
phospholipid biosynthetic process
response to virus
carboxylic acid biosynthetic process
organic acid biosynthetic process
glycerophospholipid metabolic process
cellular amino acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
small molecule biosynthetic process
positive regulation of transferase activity
perinuclear region of cytoplasm
viral process
innate immune response
symbiotic process
interspecies interaction between organisms
organophosphate metabolic process
carboxylic acid metabolic process