SERPINA1

Entrez Summary: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acute-phase response
COPII-coated ER to Golgi transport vesicle
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
platelet alpha granule lumen
vesicle coating
COPII-coated vesicle budding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
acute inflammatory response
Golgi vesicle budding
vesicle targeting
serine-type endopeptidase inhibitor activity
vesicle budding from membrane
protease binding
ficolin-1-rich granule lumen
platelet degranulation
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
negative regulation of endopeptidase activity
negative regulation of peptidase activity
blood coagulation
coagulation
hemostasis
vesicle organization
endoplasmic reticulum lumen
negative regulation of proteolysis
post-translational protein modification
establishment of organelle localization
collagen-containing extracellular matrix
Golgi vesicle transport
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
wound healing
neutrophil degranulation
neutrophil activation involved in immune response
regulation of body fluid levels
neutrophil mediated immunity