SERPINA12

Gene Information

Official Symbol: SERPINA12
Official Name: serpin family A member 12
Aliases and Previous Symbols: N/A
Entrez ID: 145264
UniProt: Q8IW75
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269|PubMed:16030142}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10996
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Cyclosporin-A 0.8μM R07 exp347	-2.04
BI-D1870 3.15μM R02 exp66	2.12

negative regulation of gluconeogenesis
positive regulation of insulin receptor signaling pathway
positive regulation of cellular response to insulin stimulus
regulation of triglyceride metabolic process
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
negative regulation of lipid biosynthetic process
regulation of cholesterol metabolic process
regulation of insulin receptor signaling pathway
regulation of cellular response to insulin stimulus
negative regulation of lipid metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
serine-type endopeptidase inhibitor activity
regulation of glucose metabolic process
regulation of steroid metabolic process
regulation of phosphatidylinositol 3-kinase signaling
regulation of cellular carbohydrate metabolic process
regulation of lipid biosynthetic process
regulation of carbohydrate metabolic process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of lipid metabolic process
regulation of endopeptidase activity
regulation of small molecule metabolic process
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
extracellular space