SERPINA3

Entrez Summary: The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

maintenance of gastrointestinal epithelium
epithelial structure maintenance
acute-phase response
platelet alpha granule lumen
acute inflammatory response
digestive system process
azurophil granule lumen
serine-type endopeptidase inhibitor activity
digestion
secretory granule lumen
platelet degranulation
blood microparticle
tissue homeostasis
negative regulation of endopeptidase activity
negative regulation of peptidase activity
multicellular organismal homeostasis
anatomical structure homeostasis
negative regulation of proteolysis
collagen-containing extracellular matrix
regulation of lipid metabolic process
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
inflammatory response
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
regulation of proteolysis
leukocyte mediated immunity
negative regulation of catalytic activity
exocytosis