SERPINA4

Entrez Summary: N/A
UniProt Summary: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. {ECO:0000269|PubMed:8227002}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet dense granule lumen
serine-type endopeptidase inhibitor activity
platelet degranulation
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulated exocytosis
regulation of proteolysis
negative regulation of catalytic activity
exocytosis
secretion by cell
negative regulation of cellular protein metabolic process
export from cell
negative regulation of protein metabolic process
secretion
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
extracellular region
vesicle-mediated transport