SERPINB1

Entrez Summary: N/A
UniProt Summary: Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. {ECO:0000269|PubMed:11747453}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

type B pancreatic cell proliferation
peptidase inhibitor activity
negative regulation of interleukin-1 beta secretion
negative regulation of interleukin-1 secretion
negative regulation of interleukin-1 beta production
negative regulation of interleukin-1 production
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
negative regulation of cytokine secretion
regulation of interleukin-1 beta production
epithelial cell proliferation
regulation of interleukin-1 production
serine-type endopeptidase inhibitor activity
secretory granule lumen
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of secretion
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of cytokine production
negative regulation of proteolysis
collagen-containing extracellular matrix
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of protein secretion
negative regulation of transport
neutrophil degranulation
neutrophil activation involved in immune response
regulation of peptide secretion
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response