SERPINB2

Entrez Summary: N/A
UniProt Summary: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fibrinolysis
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
negative regulation of wound healing
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
serine-type endopeptidase inhibitor activity
regulation of wound healing
regulation of response to wounding
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
negative regulation of response to external stimulus
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
wound healing
regulation of body fluid levels
response to wounding
cytokine-mediated signaling pathway
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
cellular response to cytokine stimulus
negative regulation of cellular protein metabolic process
regulation of response to external stimulus
response to cytokine
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of multicellular organismal process
regulation of hydrolase activity
regulation of response to stress