SERPINB4 [The Human Chemical-Genetic Interaction Map Project]

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======= SERPINB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINB4
  * **<color #00a2e8>Official Name</color>**: serpin family B member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6318|6318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48594|P48594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600518|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a protease inhibitor to modulate the host immune response against tumor cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protection from natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of cell killing|
|negative regulation of lymphocyte mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated immunity|
|negative regulation of innate immune response|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of response to biotic stimulus|
|serine-type endopeptidase inhibitor activity|
|regulation of cell killing|
|protease binding|
|negative regulation of immune effector process|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|enzyme binding|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|regulation of response to biotic stimulus|
|regulation of proteolysis|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|regulation of hydrolase activity|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17088
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINB4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>