SERPINB4

Gene Information

Official Symbol: SERPINB4
Official Name: serpin family B member 4
Aliases and Previous Symbols: N/A
Entrez ID: 6318
UniProt: P48594
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017].
UniProt Summary: May act as a protease inhibitor to modulate the host immune response against tumor cells.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17088
Expression level (log2 read counts): -7.68

Expression Distribution

protection from natural killer cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of natural killer cell mediated immunity
negative regulation of leukocyte mediated cytotoxicity
negative regulation of cell killing
negative regulation of lymphocyte mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
negative regulation of leukocyte mediated immunity
negative regulation of innate immune response
regulation of leukocyte mediated cytotoxicity
negative regulation of response to biotic stimulus
serine-type endopeptidase inhibitor activity
regulation of cell killing
protease binding
negative regulation of immune effector process
negative regulation of immune response
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
negative regulation of defense response
negative regulation of multi-organism process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
enzyme binding
negative regulation of proteolysis
negative regulation of response to external stimulus
regulation of endopeptidase activity
negative regulation of immune system process
regulation of peptidase activity
regulation of innate immune response
negative regulation of hydrolase activity
regulation of immune effector process
regulation of response to biotic stimulus
regulation of proteolysis
regulation of defense response
regulation of multi-organism process
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
regulation of response to external stimulus
negative regulation of protein metabolic process