SERPINB7 [The Human Chemical-Genetic Interaction Map Project]

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======= SERPINB7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINB7
  * **<color #00a2e8>Official Name</color>**: serpin family B member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8710|8710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75635|O75635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINB7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINB7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603357|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of platelet-derived growth factor production|
|regulation of platelet-derived growth factor production|
|positive regulation of glomerular mesangial cell proliferation|
|positive regulation of transforming growth factor beta1 production|
|positive regulation of cell proliferation involved in kidney development|
|regulation of glomerular mesangial cell proliferation|
|regulation of transforming growth factor beta1 production|
|positive regulation of glomerulus development|
|regulation of cell proliferation involved in kidney development|
|regulation of glomerulus development|
|positive regulation of transforming growth factor beta production|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|regulation of transforming growth factor beta production|
|regulation of collagen biosynthetic process|
|positive regulation of kidney development|
|regulation of collagen metabolic process|
|regulation of kidney development|
|serine-type endopeptidase inhibitor activity|
|positive regulation of vasculature development|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|regulation of vasculature development|
|negative regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|regulation of cytokine production|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|positive regulation of cell population proliferation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINB7 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>