SERPINB7

Gene Information

Official Symbol: SERPINB7
Official Name: serpin family B member 7
Aliases and Previous Symbols: N/A
Entrez ID: 8710
UniProt: O75635
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14121
Expression level (log2 read counts): -7.68

Expression Distribution

positive regulation of platelet-derived growth factor production
regulation of platelet-derived growth factor production
positive regulation of glomerular mesangial cell proliferation
positive regulation of transforming growth factor beta1 production
positive regulation of cell proliferation involved in kidney development
regulation of glomerular mesangial cell proliferation
regulation of transforming growth factor beta1 production
positive regulation of glomerulus development
regulation of cell proliferation involved in kidney development
regulation of glomerulus development
positive regulation of transforming growth factor beta production
positive regulation of collagen biosynthetic process
positive regulation of collagen metabolic process
regulation of transforming growth factor beta production
regulation of collagen biosynthetic process
positive regulation of kidney development
regulation of collagen metabolic process
regulation of kidney development
serine-type endopeptidase inhibitor activity
positive regulation of vasculature development
negative regulation of endopeptidase activity
negative regulation of peptidase activity
regulation of vasculature development
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of cytokine production
negative regulation of hydrolase activity
regulation of cytokine production
regulation of proteolysis
negative regulation of catalytic activity
positive regulation of cell population proliferation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
positive regulation of developmental process
extracellular space
regulation of cell population proliferation
positive regulation of multicellular organismal process