SERPINE2
Gene Information
- Official Symbol: SERPINE2
- Official Name: serpin family E member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5270
- UniProt: P07093
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
- UniProt Summary: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Pfam Domains GO Terms
Pfam Domains
| Serpin |
GO Terms
| mating plug formation |
| seminal vesicle epithelium development |
| post-mating behavior |
| seminal vesicle development |
| negative regulation of plasminogen activation |
| extrinsic component of external side of plasma membrane |
| cerebellar granular layer morphogenesis |
| negative regulation of platelet aggregation |
| positive regulation of astrocyte differentiation |
| insemination |
| negative regulation of phosphatidylinositol 3-kinase signaling |
| regulation of timing of cell differentiation |
| cerebellar granular layer development |
| regulation of plasminogen activation |
| platelet alpha granule |
| regulation of development, heterochronic |
| copulation |
| negative regulation of homotypic cell-cell adhesion |
| negative regulation of sodium ion transport |
| regulation of platelet aggregation |
| negative regulation of platelet activation |
| mating behavior |
| glycosaminoglycan binding |
| regulation of homotypic cell-cell adhesion |
| innervation |
| regulation of astrocyte differentiation |
| reproductive behavior |
| detection of mechanical stimulus involved in sensory perception |
| negative regulation of smoothened signaling pathway |
| cerebellar cortex morphogenesis |
| regulation of platelet activation |
| negative regulation of protein processing |
| mating |
| negative regulation of protein maturation |
| secretory granule organization |
| cerebellum morphogenesis |
| hindbrain morphogenesis |
| positive regulation of glial cell differentiation |
| detection of mechanical stimulus |
| cerebellar cortex development |
| long-term synaptic potentiation |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| extracellular vesicle |
| regulation of protein processing |
| regulation of protein maturation |
| positive regulation of gliogenesis |
| regulation of synaptic transmission, glutamatergic |
| regulation of glial cell differentiation |
| negative regulation of wound healing |
| neuromuscular junction |
| regulation of smoothened signaling pathway |
| regulation of blood coagulation |
| nerve development |
| regulation of hemostasis |
| regulation of coagulation |
| negative regulation of response to wounding |
| regulation of sodium ion transport |
| serine-type endopeptidase inhibitor activity |
| cerebellum development |
| metencephalon development |
| regulation of gliogenesis |
| detection of external stimulus |
| regulation of phosphatidylinositol 3-kinase signaling |
| detection of abiotic stimulus |
| negative regulation of protein catabolic process |
| regulation of wound healing |
| negative regulation of ion transport |
| hindbrain development |
| positive regulation of synaptic transmission |
| regulation of response to wounding |
| sensory perception of mechanical stimulus |
| heparin binding |
| negative regulation of cell-cell adhesion |
| negative regulation of cell growth |
| regulation of synaptic plasticity |
| negative regulation of cell activation |
| multi-multicellular organism process |
| response to mechanical stimulus |
| negative regulation of growth |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| negative regulation of cell adhesion |
| blood coagulation |
| coagulation |
| hemostasis |
| vesicle organization |
| negative regulation of catabolic process |
| signaling receptor binding |
| negative regulation of proteolysis |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| regulation of cell-cell adhesion |
| gland development |
| regulation of cell growth |
| regulation of endopeptidase activity |
| endomembrane system organization |
| reproductive structure development |
| reproductive system development |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| positive regulation of neurogenesis |
| wound healing |
| negative regulation of transport |
| regulation of body fluid levels |
| negative regulation of intracellular signal transduction |
| positive regulation of nervous system development |
| positive regulation of cell development |
| detection of stimulus involved in sensory perception |
| behavior |
| response to wounding |
| regulation of cell activation |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| detection of stimulus |
| regulation of ion transport |
| regulation of proteolysis |
| brain development |
| head development |
| negative regulation of catalytic activity |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| sensory perception |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| regulation of catabolic process |
| secretion by cell |
| negative regulation of cellular protein metabolic process |
| export from cell |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| epithelium development |
| secretion |
| negative regulation of molecular function |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| regulation of response to stress |
| generation of neurons |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| YM155 0.0002μM R01 exp61 | -1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11445
- Expression level (log2 read counts): 5.06
Expression Distribution
SERPINE2 Expression in NALM6 Cells: 5.06
