SERPING1

Gene Information

Official Symbol: SERPING1
Official Name: serpin family G member 1
Aliases and Previous Symbols: N/A
Entrez ID: 710
UniProt: P05155
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3269
Expression level (log2 read counts): -7.68

Expression Distribution

regulation of complement activation, lectin pathway
negative regulation of complement activation, lectin pathway
negative regulation of complement activation
negative regulation of humoral immune response
blood coagulation, intrinsic pathway
fibrinolysis
blood coagulation, fibrin clot formation
protein activation cascade
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
negative regulation of innate immune response
platelet alpha granule lumen
negative regulation of wound healing
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
negative regulation of response to biotic stimulus
serine-type endopeptidase inhibitor activity
regulation of complement activation
negative regulation of immune effector process
platelet degranulation
regulation of humoral immune response
regulation of wound healing
blood microparticle
negative regulation of immune response
complement activation, classical pathway
regulation of response to wounding
humoral immune response mediated by circulating immunoglobulin
complement activation
immunoglobulin mediated immune response
negative regulation of defense response
B cell mediated immunity
negative regulation of multi-organism process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
lymphocyte mediated immunity
aging
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains