SERTAD1

Entrez Summary: N/A
UniProt Summary: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.71
Milciclib 2μM R08 exp502	1.84

regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
regulation of protein serine/threonine kinase activity
regulation of protein kinase activity
regulation of kinase activity
positive regulation of cell population proliferation
regulation of transferase activity
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
regulation of protein phosphorylation
positive regulation of transcription, DNA-templated
regulation of phosphorylation
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process