SESN3

Entrez Summary: N/A
UniProt Summary: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000250|UniProtKB:Q9CYP7, ECO:0000269|PubMed:25263562}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

oxidoreductase activity, acting on peroxide as acceptor
TORC2 signaling
leucine binding
cellular response to leucine
cellular response to leucine starvation
TORC2 complex
response to leucine
GATOR2 complex
negative regulation of TORC1 signaling
TOR signaling
regulation of response to reactive oxygen species
regulation of TORC1 signaling
cellular response to glucose starvation
cellular response to amino acid starvation
response to amino acid starvation
negative regulation of TOR signaling
regulation of insulin receptor signaling pathway
positive regulation of macroautophagy
cellular response to amino acid stimulus
regulation of cellular response to insulin stimulus
regulation of response to oxidative stress
regulation of TOR signaling
response to amino acid
positive regulation of autophagy
cellular response to starvation
regulation of macroautophagy
glucose homeostasis
carbohydrate homeostasis
response to starvation
cellular response to acid chemical
regulation of protein kinase B signaling
response to insulin
cellular response to nutrient levels
cellular response to extracellular stimulus
regulation of autophagy
cellular response to external stimulus
response to acid chemical
positive regulation of cellular catabolic process
response to peptide hormone
positive regulation of catabolic process