SETD3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 1μM R06 exp286	1.7
Erlotinib 10μM R05 exp216	1.76

Rubis-subs-bind
SET

peptidyl-histidine methylation
protein-histidine N-methyltransferase activity
actin modification
histone methyltransferase activity (H3-K36 specific)
histone H3-K36 methylation
regulation of uterine smooth muscle contraction
peptidyl-histidine modification
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
histone methyltransferase activity (H3-K4 specific)
protein-lysine N-methyltransferase activity
peptidyl-lysine trimethylation
histone H3-K4 methylation
RNA polymerase II activating transcription factor binding
regulation of smooth muscle contraction
histone lysine methylation
positive regulation of muscle cell differentiation
peptidyl-lysine methylation
histone methylation
protein alkylation
protein methylation
regulation of muscle cell differentiation
regulation of muscle contraction
regulation of muscle system process
nuclear chromatin
macromolecule methylation
actin binding
transcription coactivator activity
methylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
actin cytoskeleton organization
actin filament-based process
regulation of system process
chromatin organization
peptidyl-amino acid modification
positive regulation of cell differentiation
chromosome organization
cytoskeleton organization