SETD5

Gene Information
  • Official Symbol: SETD5
  • Official Name: SET domain containing 5
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 55209
  • UniProt: Q9C0A6
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017].
  • UniProt Summary: Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription. {ECO:0000250|UniProtKB:Q5XJV7}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 7608
  • Expression level (log2 read counts): 7.58

Expression Distribution

  • Last modified: 2026/01/07 22:37
  • by 127.0.0.1